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Главная / Архив / 2025 год / MEDICUS № 10 (76), October / BIOACTIVE COMPOUNDS AND THERAPEUTIC APPLICATIONS OF CEDAR ESSENTIAL OIL IN WOUND HEALING (REVIEW)

BIOACTIVE COMPOUNDS AND THERAPEUTIC APPLICATIONS OF CEDAR ESSENTIAL OIL IN WOUND HEALING (REVIEW)

Дата публикации: 24.10.2025

UDC 615.322.2; 57.08

 

BIOACTIVE COMPOUNDS AND THERAPEUTIC APPLICATIONS

OF CEDAR ESSENTIAL OIL IN WOUND HEALING (REVIEW)

 

A.M. Kaliyeva, PhD, Associate Professor without academic title

Asfendiyarov Kazakh National Medical University

(050012, Kazakhstan, Almaty, Tole bi str. 94)

Е-mail: kalieva.a@kaznmu.kz

 

Abstract. Сedar essential oil, obtained from various coniferous species of the genera Pinus and Cedrus, is a natural product rich in bioactive compounds such as terpenes, polyphenols, essential fatty acids, and vitamins. Oil extracted from the seeds of Pinus sibirica (Siberian cedar), widely distributed across Siberia, Kazakhstan, the Altai region, and Mongolia, is particularly abundant in fatty acids and antioxidants that promote skin regeneration and wound healing. Essential oils derived from true cedars (Cedrus atlantica, Cedrus libani, and Cedrus deodara), native to the Mediterranean region (Morocco, Lebanon, Turkey) and the Himalayas (India, Pakistan), contain sesquiterpenes like cedrol, known for their potent antimicrobial and anti-inflammatory properties. Other notable sources include Pinus koraiensis (Korean pine) in China and Korea, and Pinus cembra (Swiss stone pine), which grows naturally in the Alps and Carpathians. This review summarizes the bioactive components of cedar oils, elucidates their mechanisms of action in wound healing, discusses recent advances in extraction technologies, and explores current biomedical applications and safety considerations, highlighting the therapeutic potential of cedar oil as a natural agent for skin repair and regeneration.

Keywords: cedar oil, bioactive components, wound healing, skin regeneration, antioxidants, natural products.

 

  1. Introduction

Wound healing is a complex biological process essential for restoring the integrity and function of damaged skin. Despite advances in modern medicine, the development of effective treatments that accelerate tissue repair and minimize complications remains a significant challenge.

In this regard, medicinal plants have been used for centuries across various cultures worldwide to treat wounds. Natural products, especially plant-derived extracts and essential oils (EO), have attracted considerable attention due to their bioactive compounds, which promote tissue regeneration, reduce inflammation, and exhibit antimicrobial properties [3, 32, 40, 47].

The recent resurgence of interest in phytotherapy reflects not only its traditional use but also its growing importance in modern biomedical research. Plant-derived compounds are actively studied both as therapeutic agents and as components of innovative delivery systems, such as polysaccharide-based hydrogels. In particular, recent clinical and experimental studies have focused on their effects on wound tissue regeneration, achieving significant progress in understanding the mechanisms by which phytotherapeutic agents facilitate the healing of diabetic and burn wounds [47].

Among the many plant-derived substances under investigation, cedar essential oil (CEO) stands out as a particularly promising natural product due to its rich profile of bioactive compounds and therapeutic properties [43]. Obtained from various coniferous species of the genera Pinus and Cedrus, cedar oil contains terpenes, polyphenols, essential fatty acids, and vitamins, which contribute to its wound-healing potential [9]. The chemical composition and biological activities of CEO vary depending on the species and geographical origin. For example, oil extracted from the seeds of Pinus sibirica (Siberian cedar), which grows extensively across Siberia, Kazakhstan, the Altai region, and Mongolia, is particularly rich in fatty acids and antioxidants that support skin regeneration and wound healing. EOs derived from true cedars such as Cedrus atlantica, Cedrus libani, and Cedrus deodara, native to the Mediterranean region (Morocco, Lebanon, Turkey) and the Himalayas (India, Pakistan), contain sesquiterpenes like cedrol, which exhibit potent antimicrobial and anti-inflammatory activities. Other significant sources include Pinus koraiensis (Korean pine), found in China and Korea, and Pinus cembra (Swiss stone pine), which grows naturally in the Alps and Carpathians. Each species contributes a distinct profile of bioactive compounds, which influences the oil’s efficacy in various biomedical applications [5, 25, 42]. Other noteworthy sources of cedar oil include Pinus sylvestris (Scots pine), native to Europe and parts of Asia, whose oil is commonly used for its soothing and antiseptic properties in treating respiratory ailments and skin irritations. Pinus nigra (Black pine), found in Southern Europe, is also a valuable source of essential oils rich in antioxidants and flavonoids, contributing to its anti-inflammatory and wound-healing effects. Additionally, Pinus pinaster (Maritime pine), predominantly found in coastal areas of the Mediterranean, is known for its high concentration of proanthocyanidins, potent antioxidants that aid in skin regeneration and collagen synthesis. The oils from these species are also known for their analgesic and antibacterial properties, which make them effective in treating various skin conditions, including minor burns, cuts, and infections [1, 11, 27, 34, 35, 38]. Each of these pine species, along with true cedars, offers a unique chemical composition, making cedar oil a versatile and promising natural remedy in both traditional and modern medicine. Some examples of these species are illustrated in Figure 1.

 

Cedrus atlantica

(Atlas Cedar) [1]

Cedrus libani

(Lebanon Cedar) [2]

Cedrus deodara

(Himalayan Cedar) [3]

 

 

Pinus sibirica

(Siberian Cedar) [4]

Pinus koraiensis

(Korean Pine) [5]

Eastern White Pine

(Pinus strobus) [6]

 

Figure 1. Different Species of Cedar Trees and Their Seeds

 

* Images were sourced from the following links:

[1] https://www.flower-db.com/en/flowers/cedrus-libani

[2] https://www.researchgate.net/publication/336915518_Forest_Arabesques/figures?lo=1

[3] https://www.uc3m.es/ss/Satellite/Sostenibilidad/en/TextoDosColumnas/1371335891561/Cedro_del_Himalaya

[4] https://www.reddit.com/r/marijuanaenthusiasts/comments/qp2di9/the_eastern_white_pine_has_needles_of_5_that_can/

[5] https://conifers.org/pi/Pinus_koraiensis.php

[6] https://www.conifers.org/pi/Pinus_strobus.php

 

This review aims to comprehensively summarize the bioactive components present in cedar oils, elucidate their mechanisms of action in wound healing, discuss recent advances in extraction technologies, and explore current biomedical applications along with safety considerations. Through this summary, the therapeutic potential of CEO as a natural agent for skin repair and regeneration is presented.

 

  1. Bioactive Components of CEO

The analysis of the chemical composition of the CEO has been conducted in numerous studies by various researchers, highlighting regional differences in the essential oil composition, which are influenced by factors such as climate, soil, and cultivation methods. For instance, oils derived from Cedrus atlantica (Atlas cedar), native to the Mediterranean region, are particularly rich in sesquiterpenes, such as cedrol, which is renowned for its potent antimicrobial and anti-inflammatory properties [8, 14]. These oils have been extensively studied for their potential in treating infections and promoting skin regeneration.

This study, conducted by Bennouna et al. (2019), investigated the chemical composition and antimicrobial effects of Cedrus atlantica EO against bacteria and fungi responsible for degrading cedar wood. Gas chromatography (GC)/mass spectrometry (MS) analysis revealed that cedranone and iso-cedranol were the major components of the essential oil. The oil exhibited significant antibacterial activity against two bacterial strains, with minimum inhibitory concentrations (MICs) ranging from 1% to 2%, and antifungal activity against six fungal species, with MICs ranging from 0.5% to 1%. Such antimicrobial properties make Cedrus atlantica essential oil a promising candidate for wound healing applications, as preventing bacterial and fungal infections is crucial for promoting effective wound recovery. Furthermore, the treatment with the essential oil preserved the physicochemical properties of cedar wood, maintaining its hydrophobic nature and enhancing its electron donor properties after exposure for 15 minutes to 1 hour, which could also contribute to the protective effect in skin regeneration [8]. The study by El Hachlafi et al. (2023) investigates the essential oils (CAEO) of Cedrus atlantica and examines their volatile compounds as well as their biological properties, including antimicrobial, antioxidant, anti-inflammatory, and dermatoprotective effects. The GC-MS analysis identified β-himachalene, α-himachalene, and longifolene as the primary components of CAEO. Antimicrobial testing showed strong antibacterial and antifungal activity, with low MIC and MBC values, indicating both bactericidal and fungicidal effects. The essential oils also exhibited significant antioxidant activity and inhibited key enzymes, including 5-LOX and tyrosinase, which are associated with inflammation and skin protection. In silico ADMET analysis suggested favorable pharmacokinetic properties for the major compounds in CAEO. This research provides scientific validation for the traditional use of Cedrus atlantica and suggests its potential for development into natural therapeutic agents [11, 2].

The study by Amara et al., (2025) [4] examines the antimicrobial potential of Cedrus atlantica (Atlas cedar) EO. The extraction yield was 0.53%, and the oil met AFNOR standards. The chemical analysis revealed 15 volatile compounds, with α-Pinene, β-Himachalene, α-Himachalene, Myrcene, and α-Terpineol being the main constituents. Antimicrobial tests showed significant inhibition of both Gram-positive and Gram-negative bacteria, as well as selective activity against fungi. The volatility of EO components also played a role in their bactericidal activity. In silico ADME/T analysis indicated that the major compounds have drug-like properties, with some concerns about lipophilicity, but they generally follow drug-likeness rules and are promising for oral use. Bioavailability assessments were favorable. Molecular docking studies showed that β-Himachalene, with a binding energy of -7.5 kcal/mol, closely rivaled the drug Trimethoprim (-7.6 kcal/mol) in inhibiting Staphylococcus aureus DHFR, suggesting the potential for antimicrobial drug development. Overall, the study highlights the promising antimicrobial and drug-like potential of Cedrus atlantica EO for sustainable medicinal applications.

In contrast, oils derived from Pinus sibirica (Siberian cedar), typically grown in colder regions such as Siberia and Kazakhstan, are rich in fatty acids and antioxidants, including tocopherols (vitamin E). These bioactive compounds make Siberian cedar oil particularly beneficial for skin repair and protection against oxidative stress. Research on Siberian CEO often highlights its role in wound healing and its anti-aging effects, primarily due to its strong antioxidant profile. While the study by Shikov et al. (2008) mainly focuses on the anti-inflammatory, analgesic, and antipyretic properties of Pinus sibirica oil extract, the observed anti-inflammatory effects may also suggest potential benefits for skin regeneration. Given the critical role of inflammation in tissue repair, Pinus sibirica oil extract, with its rich composition of polyunsaturated fatty acids, tocopherols, and polyphenols, could hold promise for further applications in dermatological and regenerative medicine [39]. Pinus sibirica oil extract, with its rich composition of polyunsaturated fatty acids, tocopherols, and polyphenols, holds significant promise for applications in dermatological and regenerative medicine. In line with this, a recent study by Nikolic et al. (2023) [25] demonstrated the efficacy of Siberian pine essential oil formulations in promoting wound healing, particularly in diabetic conditions. The study highlighted that both ointment and gel formulations containing 0.5% Siberian pine essential oil (SPEO) significantly reduced wound size in a diabetic rat model, achieving up to 98.14% and 96.28% healing, respectively. These formulations not only promoted tissue repair but also enhanced the antioxidant defense system, reducing pro-oxidants and increasing collagen content in the tissue. Such results underline the potential of Siberian pine oil as a natural therapeutic agent in regenerative medicine, particularly for improving wound healing and skin regeneration [26]. According to this study, this is the first investigation into the acute dermal irritation of Pinus sibirica ointment and gel. In their experiment, animals exposed to both PSEO ointment and PSEO gel did not exhibit any adverse reactions, such as edema, erythema, pruritus, or inflammation, nor were there any clinical signs of dermal toxicity. Additionally, no noticeable behavioral changes were observed over the 14-day period (fig. 2) [26].

Figure 3

 

Figure 2. Impact of P. sibirica essential oil-based formulations on wound recovery during three weeks of application on the excision wound model (days: 0, 7, 14, and 21). CTRL-untreated control group; SSD-1% silver sulfadiazine group; OINT-ointment base group; GEL-gel base group; PSOINT-P. sibirica essential oil ointment group; PSGEL-P. sibirica essential oil gel group [26]

 

The unique chemical composition of Pinus koraiensis oil, influenced by its geographic origin, has led to increasing interest in its therapeutic properties. Given its high content of flavonoids and polyphenols, studies have demonstrated that this oil is not only effective in combating oxidative stress and inflammation but also plays a crucial role in promoting skin regeneration. These benefits make it a promising candidate for use in cosmetic formulations and topical treatments aimed at improving skin health, reducing signs of aging, and alleviating pain. Furthermore, ongoing research is exploring the synergy between these bioactive compounds and other plant-based ingredients to enhance the overall efficacy of dermatological products, highlighting the growing trend of integrating natural, antioxidant-rich oils into modern skincare [16, 17, 22, 23].

Research on pine nut oil (PNO) has also shown promising effects, including its ability to reduce body weight gain and lipid accumulation in muscles of mice on a high-fat diet. PNO enhances oxidative metabolism, activates AMPK, and increases the expression of genes related to type I and IIa muscle fibers. These effects are partly attributed to the activity of pinolenic acid on peroxisome proliferator-activated receptors. These findings suggest that PNO may help combat obesity and metabolic dysfunction [22].

Additionally, Pinus koraiensis (Korean pine), native to China and Korea, contains flavonoids and other polyphenolic compounds that have been shown to have strong anti-inflammatory and antioxidant effects, making this oil valuable in both dermatological treatments and pain relief. The specific profile of active components in these oils varies depending on the environmental conditions and climate in which the trees grow, highlighting the significant influence of geographic location on the chemical composition of cedar oil [16, 17].

In summary, while all cedar oils contain terpenes like alpha-pinene and beta-pinene, their therapeutic applications may differ significantly based on the specific components found in oils from different species and locations. Researchers continue to explore these differences to better understand the diverse uses of cedar oil in medicine, cosmetics, and traditional healing practices.

Cedar oil, extracted from the wood and seeds of various species of cedar trees, is rich in bioactive compounds that contribute to its therapeutic properties. One of the primary active components are terpenes, notably alpha-pinene and beta-pinene. These monoterpenes exhibit strong antiseptic, anti-inflammatory, and analgesic properties, making cedar oil particularly useful in treating inflammations and skin infections. Additionally, cedar oil contains phenolic compounds, including flavonoids and tannins, which are crucial for its antioxidant activity. These compounds neutralize free radicals, helping to protect cells from oxidative stress and slowing down the aging process of the skin [23, 24].

Another important component of cedar oil is linoleic acid (omega-3), which contributes to the improvement of cellular membrane structure and the normalization of metabolic processes in the body. This fatty acid also has anti-inflammatory effects, making it especially beneficial for skin and joint conditions. Moreover, cedar oil contains squalene, an organic compound with significant moisturizing and anti-aging properties. Squalene enhances the skin's barrier function and overall health. It also plays a role in regulating cholesterol levels, contributing to general health improvement. Together, these bioactive compounds give cedar oil a wide range of therapeutic benefits, including antibacterial, anti-inflammatory, antioxidant, and regenerative actions. This makes cedar oil a valuable tool in cosmetics, dermatology, and traditional medicine [40].

Kang et al. (2023) [20] investigated the anti-inflammatory effects of Pinus koraiensis nuts in a DNFB-induced mouse model of contact dermatitis, assessing lesion severity, skin and epithelial thickness, melanin and erythema indices, immune cell infiltration, and cytokine levels (TNF-α, IFN-γ, IL-6, and MCP-1). The local application of 0.15% DNFB to shaved skin caused symptoms such as induration, fissures, scaling, erythema, and petechiae. Treatment with EEPK for 6 days significantly alleviated these symptoms (Figure 2A). In terms of skin thickness, the CTL group had more than twice the thickness of the NOR group, while the 250 µg/day EEPK group showed a 13% reduction compared to the CTL group. Although the DEX group had a significant reduction in skin thickness, no improvement in other skin symptoms was observed (fig. 3).

 

 

 

Figure 3. Effects of EEPK on skin lesions and thickness in CD mice. Skin lesions were observed using a digital camera on day 16. (A) a, NOR; b, CTL; c, 25 µg/day EEPK; d, 75 µg/day EEPK; e, 250 µg/day EEPK; f, DEX. (B) NOR, non-treated-naïve group; CTL, non-treated CD group; EEPK, ethanol extract of P. koraiensis seed treated CD groups; DEX, dexamethasone-treated CD group. A. U. means arbitrary units. (C) Skin thicknesses were measured using a Vernier calipers. All values are expressed as means ± standard deviations. ###P < 0.001 versus the NOR group (non-treated-naïve controls); ***P < 0.001 versus the CTL group (non-treated CD group) [20]

 

Comparative analysis of cedar essential oils from different species and regions demonstrates that geographical origin has a decisive impact on their chemical composition and therapeutic efficacy. In particular, oils from Cedrus atlantica, C. libani, and C. deodara are characterized by a high content of sesquiterpenes such as cedrol and himachalene, which in turn determine their pronounced antimicrobial and anti-inflammatory activities. Conversely, oils from Pinus sibirica and P. koraiensis are rich in fatty acids, tocopherols, and polyphenols, thereby enhancing their antioxidant and regenerative potential in wound healing. Thus, environmental factors and species-specific metabolism directly shape the bioactive profile of cedar oils, influencing their suitability for various biomedical and cosmetic applications. Consequently, understanding these variations allows for the targeted use of specific cedar species to maximize therapeutic outcomes in skin repair and regeneration.

 

  1. Advances in Extraction Technologies of CEO

The method of oil extraction plays a crucial role in determining its composition and biological activity, which in turn significantly affects its effectiveness in wound healing, skincare, and other medical applications. Several methods are used to extract cedar oil, with steam distillation and solvent extraction being the most common. These methods not only influence the yield of the oil but also determine which bioactive components are preserved, directly impacting its therapeutic potential [6, 30, 10].

The composition and biological activity of cedar oil can be significantly influenced by the extraction method used. Steam distillation, for example, typically preserves key terpenoid components such as alpha-pinene, beta-pinene, and cedrol, which are responsible for the oil's potent antimicrobial and anti-inflammatory properties. These compounds are vital for tissue regeneration, making cedar oil especially effective for treating wounds and inflammation [12, 15, 19, 29].

On the other hand, oils extracted using solvent methods tend to contain higher concentrations of fatty acids, such as linoleic acid, which are essential for maintaining cellular membrane integrity and supporting tissue repair. Linoleic acid also possesses strong anti-inflammatory properties, making these oils particularly beneficial for treating skin conditions like eczema and acne [33, 46].

The extraction method also depends on the species of cedar and its geographical origin, further influencing the oil's properties. For instance, oil extracted from the seeds of Pinus sibirica is rich in fatty acids and antioxidants, such as vitamin E, which promote skin regeneration and help slow down aging. In contrast, oil from Cedrus atlantica contains higher levels of cedrol, a compound with potent antimicrobial properties, making it particularly effective for treating infections and inflammation [31, 21].

Recent advancements in extraction technologies are focused on improving both the yield and quality of cedar oil while minimizing the degradation of bioactive compounds. Techniques such as ultrasonic extraction and supercritical CO2 extraction have shown promising results, allowing for the extraction of essential oils with minimal loss of active ingredients and without the use of chemical solvents. These cutting-edge methods enable the production of purer, more effective oils, which are essential for their use in medical and cosmetic applications [13, 44].

Supercritical CO2 has proven to be an effective and selective method for extracting essential oils from plant materials. This process leverages the solvent power of supercritical CO2, with the interaction between the solvent and solute being adjustable based on various operational parameters. By modifying these conditions, the solubility of the essential oil can be enhanced, leading to a higher yield. One of the key benefits of supercritical CO2 is that it possesses both gas and liquid properties, allowing it to extract the oil without leaving any residual solvents behind [36].

The extraction of cedarwood oil (CWO) using supercritical CO2 (SC-CO2) and liquid CO2 (LC-CO2) was studied, focusing on how temperature, pressure, and extraction duration affect the oil's composition. SC-CO2 extraction, especially at 100°C and 6000 psi, yielded the highest extraction rate, with average yields ranging from 3.55% to 3.88% across various conditions. The oil extracted by SC-CO2 had a higher concentration of thujopsene and was closer to the original cedarwood chips in sensory evaluation compared to steam-distilled oil. Additionally, a lower cedrol/cedrene ratio was observed at higher temperatures (100°C) for SC-CO2 extraction, while the highest ratio occurred at 25°C and 1500 psi. LC- CO2 showed no significant variation in extraction rates at 25°C with different pressures. Subcritical water extraction was also explored but resulted in lower yields and off odors at higher temperatures, as high heat and acidic conditions led to the conversion of cedrol to cedrene. Overall, SC- CO2 extraction was found to be more efficient, with a better quality profile, compared to other methods [7, 28].

Supercritical carbon dioxide (scCO2) extraction is a promising technique that uses CO2 in its supercritical state as a solvent, replacing traditional organic solvents. This method offers several advantages over conventional technologies, including higher solubility, greater selectivity, improved mass transfer rates, and the elimination of the need for further refining to separate the extracted oil. The selectivity of the extracted components depends on the density of the supercritical fluid, which can be adjusted by varying the process conditions. Figure 4 illustrates a schematic diagram of the scCO2 extraction process, where raw materials are placed in the extraction vessel, and с is pumped into the vessel until it reaches supercritical conditions [41].

 

 

Figure 4. Experimental setup of Supercritical Carbon Dioxide Extraction technology

for the extraction and separation of oil from various plant matrices [41]

The extraction method is a key factor influencing the composition, biological activity, and therapeutic potential of cedar essential oil. Traditional methods like steam distillation and solvent extraction each have distinct advantages and drawbacks. Steam distillation is effective in preserving essential terpenoid compounds, such as alpha-pinene and cedrol, which are critical for antimicrobial and anti-inflammatory effects. However, solvent extraction tends to yield oils with higher concentrations of fatty acids like linoleic acid, which are beneficial for skin regeneration and tissue repair.

Recent advancements in extraction technologies, particularly ultrasonic and supercritical CO2 (SC-CO2) extraction, have proven to enhance both yield and quality while minimizing the degradation of bioactive compounds. SC-CO2extraction, in particular, offers a promising alternative by eliminating the need for chemical solvents, increasing the solubility of oils, and yielding high-quality, pure extracts. This method allows for better control of the oil composition, such as the ratio of thujopsene and cedrol, which can be optimized depending on temperature and pressure conditions.

Overall, SC-CO2 extraction stands out due to its higher yield, efficiency, and purity, making it a superior option for producing cedar oil with a more consistent and beneficial profile for medical and cosmetic applications. Moreover, the use of supercritical CO2’s dual gas-liquid properties offer the added benefit of cleaner extractions, free from residual solvents, which is essential for ensuring the safety and efficacy of the final product. These advancements are paving the way for more sustainable and effective methods of essential oil extraction, supporting a growing demand for high-quality, natural products.

 

4. Conclusion

As a final point, essential oils derived from various cedar species demonstrate considerable potential in regenerative medicine due to their bioactive components, including terpenes, fatty acids, and antioxidants. These oils possess powerful properties that promote tissue regeneration, accelerate wound healing, and protect against oxidative stress. Different cedar species, such as Cedrus atlantica and Pinus sibirica, offer distinct chemical profiles, making them highly suitable for targeted treatments of skin conditions, inflammation, and tissue repair. Furthermore, advanced extraction technologies like supercritical CO2 extraction enable the production of oils with minimal loss of active ingredients, enhancing their therapeutic efficacy in regenerative medicine.

The analytical review was conducted under the grant funding provided by the Ministry of Science and Higher Education of the Republic of Kazakhstan.

 

The analytical review was conducted under the grant funding program for young scientists “Zhas Galym” for 2024-2026, of the Ministry of Science and Higher Education of the Republic of Kazakhstan, project title “Development of new bactericidal biocomposites based on biopolymers with silver nanoparticles, stabilized with plant extracts with a fast wound healing effect”, grant number AP22684163.

 

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  46. Xie, M., Jiang, Z., Lin, X., Wei, X. Application of Plant Extracts Cosmetics in the Field of Anti-Aging // Journal of Dermatologic Science and Cosmetic Technology. – 2024. – Vol. 1, No. 2. – Article No. 100014. – https://doi.org/10.1016/j.jdsct.2024.100014.
  47. Yan, R., Wang, Y., Li, W., Sun, J. Promotion of Chronic Wound Healing by Plant-Derived Active Ingredients and Research Progress and Potential of Plant Polysaccharide Hydrogels // Chin. Herb. Med. – 2025. – Vol. 17(1). – Pp. 70-83. https://doi.org/10.1016/j.chmed.2024.11.005.

 

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46. Xie M., Jiang Z., Lin X., Wei X. Application of Plant Extracts Cosmetics in the Field of Anti-Aging. Journal of Dermatologic Science and Cosmetic Technology. 2024. Vol. 1, No. 2. Article No. 100014. https://doi.org/10.1016/j.jdsct.2024.100014.

47. Yan R., Wang Y., Li W., Sun J. Promotion of Chronic Wound Healing by Plant-Derived Active Ingredients and Research Progress and Potential of Plant Polysaccharide Hydrogels. Chin. Herb. Med. 2025. Vol. 17(1). Pp. 70-83. https://doi.org/10.1016/j.chmed.2024.11.005.

 

Материал поступил в редакцию 01.10.25

 

 

БИОАКТИВНЫЕ КОМПОНЕНТЫ И ТЕРАПЕВТИЧЕСКОЕ ЗНАЧЕНИЕ

КЕДРОВОГО ЭФИРНОГО МАСЛА ДЛЯ ЗАЖИВЛЕНИЯ РАН (ОБЗОР)

 

А.М. Калиева, PhD, ассоциированный профессор без ученого звания

Казахский национальный медицинский университет имени С.Д. Асфендиярова

(050012, Казахстан, г. Алматы, ул. Толе би 94)

Е-mail: kalieva.a@kaznmu.kz

 

Аннотация. Эфирное масло кедра, получаемое из различных хвойных видов родов Pinus и Cedrus, является природным продуктом, богатым биоактивными соединениями, такими как терпены, полифенолы, незаменимые жирные кислоты и витамины. Масло, извлекаемое из семян Pinus sibirica (сибирский кедр), широко распространенного в Сибири, Казахстане, Алтайском крае и Монголии, особенно богато жирными кислотами и антиоксидантами, которые способствуют регенерации кожи и заживлению ран. Эфирные масла, получаемые из настоящих кедров (Cedrus atlantica, Cedrus libani и Cedrus deodara), произрастающих в Средиземноморье (Марокко, Ливан, Турция) и Гималаях (Индия, Пакистан), содержат сесквитерпены, такие как цедрол, известные своими мощными антимикробными и противовоспалительными свойствами. Другими значимыми источниками являются Pinus koraiensis (корейский кедр) в Китае и Корее, а также Pinus cembra (швейцарский каменный кедр), который естественно произрастает в Альпах и Карпатах. Этот обзор резюмирует биоактивные компоненты кедровых масел, разъясняет их механизмы действия при заживлении ран, обсуждает последние достижения в технологиях экстракции и исследует текущие биомедицинские применения и вопросы безопасности, подчеркивая терапевтический потенциал кедрового масла как природного агента для восстановления и регенерации кожи.

Ключевые слова: кедровое масло, биоактивные компоненты, заживление ран, регенерация кожи, антиоксиданты, натуральные продукты.